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KMID : 0614020050200010058
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Journal of Pharmaceutical Sciences (C.N.U.)
2005 Volume.20 No. 1 p.58 ~ p.63
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Antitumor immunoactivities of the combinations containing the hot water extract of Sparassis crispa
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Chung Kyeong-Soo
Lee Woo-Chan
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Abstract
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In order to develope a new composite to be used as immunopotentiating health food, the composites including extracts of Sparassis crispa, Grifola frondosa, Phellinus linteus, red ginseng, and Oxya japonica were prepared and tested for their antitumor immunoactivities. Of these, the composite G3, which contained the extracts of S. crispa (20%), G. frondosa (55%), P. linteus (5%), red ginseng (10%), and O. japonica (10%), showed marked lymphoblastogenic activity on the in vitro cultured BALB/c mouse splenic lymphocytes and successfully suppressed the growth of sarcoma 180 cells implanted into the peritoneum of ICR mice. Moreover, the composite G3 exerted antitumor activity against sarcoma 180 tumor cells subcutaneously implanted into the left groin of ICR mice with the tumor inhibition ratio of 46.2%.
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KEYWORD
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Sparassis crispa, Grifola frondosa, Phellinus linteus, red ginseng, Oxya japonica, immunopotentiating, antitumor
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